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So, the metabolite is liable for about twenty% of sildenafil's action. Sildenafil is excreted as metabolites predominantly during the feces (about eighty% of administered oral dose) and to a lesser extent during the urine (close to thirteen% in the administered oral dose). If taken that has a large-Fats meal, absorption is lowered; some time taken to reach the most plasma focus increases by all around just one hour, and the maximum concentration itself is lowered by nearly one particular-3rd.[fifty two]
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